TNF-mediated inflammatory disease
نویسندگان
چکیده
منابع مشابه
Anti-TNF Withdrawal in Inflammatory Bowel Disease
The introduction of the anti-tumor necrosis factorα agents (anti-TNFα) in clinical practice has greatly advanced the treatment of inflammatory bowel disease. The use of these medications results in durable remission in a subset of patients, preventing surgery and hospitalizations. However, there are some concerns about safety and costs associated with their long-term use. Therefore, anti-TNF wi...
متن کاملAnti-TNF Treatment in Inflammatory Bowel Disease
Crohn’s disease and ulcerative colitis are chronic inflammatory disorders of the gastrointestinal tract. Although the primary etiological defect stil remains unknown, in the last decade impotant progress has been made concerning the immunological basis of the disease. Genetic, environmental and microbial factors result in repeated activation of mucosal immune response. Tumor necrosis factor alp...
متن کاملAnti-TNF-Mediated Modulation of Prohepcidin Improves Iron Availability in Inflammatory Bowel Disease, in an IL-6-Mediated Fashion
Background. Anaemia is common in inflammatory bowel disease (IBD), frequently resulting from a combination of iron deficiency and of anaemia of chronic disease (ACD). ACD is characterized by macrophage iron retention induced by proinflammatory cytokines. Hepcidin is the master inducer of iron accumulation during ACD, and its production is mainly regulated by IL-6 and the novel erythroid hormone...
متن کاملCorrection: Inflammatory Bowel Disease: How Effective Is TNF-α Suppression?
[This corrects the article DOI: 10.1371/journal.pone.0165782.].
متن کاملTargeting TNF and Its Family Members in Autoimmune/Inflammatory Disease
Tumor necrosis factor (TNF), a pleiotropic cytokine mainly produced by activated macrophages, modulates a wide range of biological functions in multiple tissues and organs. Besides its effects on tumor cell death, TNF is a key mediator of both acute and chronic inflammation. Since the description of TNF in the 1970s and through consideration of structural homologies, a total of 19 TNF-related c...
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ژورنال
عنوان ژورنال: The Journal of Pathology
سال: 2008
ISSN: 0022-3417,1096-9896
DOI: 10.1002/path.2287